Developmental Genetics of Secretory Vesicle Acidification during C. elegans Spermatogenesis
نویسندگان
چکیده
Developmental Genetics of Secretory Vesicle Acidification during C. elegans Spermatogenesis Elizabeth J. Gleason, Paul D. Hartley, Melissa Henderson, Katherine L. HillHarfe, Paul W. Price, Robby M. Weimer**, Tim L. Kroft, Guang-dan Zhu, Suzanne Cordovado* and Steven W. L’Hernault *Department of Biology, Graduate Programs in †±Genetics and Molecular Biology and ‡Biochemistry, Cell and Developmental Biology, Emory University, Atlanta, GA 30322; Abeome Corp., Athens, GA 30605; **Department of Biology, University of Utah, Salt Lake City, UT 84112
منابع مشابه
Developmental genetics of secretory vesicle acidification during Caenorhabditis elegans spermatogenesis.
Secretory vesicles are used during spermatogenesis to deliver proteins to the cell surface. In Caenorhabditis elegans, secretory membranous organelles (MO) fuse with the plasma membrane to transform spermatids into fertilization-competent spermatozoa. We show that, like the acrosomal vesicle of mammalian sperm, MOs undergo acidification during development. Treatment of spermatids with the V-ATP...
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